PRP & PRF
What is PRP?
PRP is a platelet-rich plasma protein concentrate derived from whole blood and obtained after centrifugation to specific protocol.
PRP gives us:
• High concentration of autologous platelets in a small volume of plasma.
• High concentration of 7 growth factors responsible for the therapeutic and regenerative effect of PRP.
To classified as PRP, the separated plasma must be certified to have a platelet concentration of at least *5 above the base line in order to have therapeutic activity.
If the above rule is not met, the final product is not classified as PRP but as separated plasma without a proven therapeutic effect.
The effect of platelets
Platelets outside the bloodstream are activated and produce morphogenetic proteins (growth factors).
These growth factors are important for therapy in a variety of tissue types, have a synergistic effect and promote the following benefits:
- They induce proliferation and differentiation of various cell types (e.g. stem cells, osteoblasts, epidermal cells).
- They enhance/regulate the production of collagen, proteoglycans and Tissue Inhibitors of Metalloproteinases (TIMP).
- Promote angiogenesis.
- Reduce inflammation
The role of growth factors
Some of the growth factors that act therapeutically & regeneratively and are released by platelet activation are the following:
PDGF
PDGF (Platelet Derived Growth Factor), which acts mainly in the early healing phase by promoting fibroblast proliferation, TGF-β production, chemotaxis and angiogenesis.
TGF-β
(Transforming Growth Factor-β), which is a product of platelets and macrophages and promotes chemotaxis, fibroblast proliferation, collagen synthesis and angiogenesis.
VEGF
(Vascular Endothelial Growth Factor), a particularly important protein for neovascularisation during wound healing. It is stimulated by PDGF.
IGF
(Insulin-like Growth Factor), which is secreted by platelets and plays an important role in bone growth.
EGF
(Epidermal Growth Factor), secreted by platelets, which promotes the formation of granular tissue and angiogenesis by stimulating the proliferation of epithelial cells and fibroblasts.
FGF
(Fibroblast Growth Factor) affects tissue healing, cell proliferation and the production of collagen and hyaluronic acid
Clinical applications
Autologous growth factor therapy has been used for over 20 years to treat various conditions by many medical specialties:
Orthopaedics
Plastic surgery
Vascular surgery
Surgery
Maxillofacial surgery
Dermatology
Urology
Neurosurgery
Ophthalmology
MEDICAL TECHNOLOGY SOLUTIONS FROM MEDISPORTS
Our company has a complete portfolio of medical devices PRP / PRF, as well as the necessary accompanying equipment.
The systems are certified by the American FDA, the European agencies and the EOF.
